Assembly of RNA Polymerase-I Initiation Complex

Description:

The nuclei of all eukaryotic cells contain three different RNA Polymerases, designated I, II and III. Like the DNA polymerase that catalyzes DNA replication, RNA Polymerases catalyze the formation of the phosphodiester bonds that link the nucleotides together to form a linear chain. The RNA polymerase moves stepwise along the DNA, unwinding the DNA helix just ahead of the active site for polymerization to expose a new region of the template strand for complementary base-pairing. In this way, the growing RNA chain is extended ...

References:

TFIIB-related factors in RNA polymerase I transcription.
Knutson BA, Hahn S.
Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30. Review.
Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes.
Goodfellow SJ, Zomerdijk JC.
Subcell Biochem. 2013;61:211-36. doi: 10.1007/978-94-007-4525-4_10. Review.
Structure of the initiation-competent RNA polymerase I and its implication for transcription.
Pilsl M, Crucifix C, Papai G, Krupp F, Steinbauer R, Griesenbeck J, Milkereit P, Tschochner H, Schultz P.
Nat Commun. 2016 Jul 15; 7:12126. doi: 10.1038/ncomms12126.
Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body.
Hamdane N, Stefanovsky VY, Tremblay MG, Németh A, Paquet E, Lessard F, Sanij E, Hannan R, Moss T.
PLoS Genet. 2014 Aug 14; 10(8):e1004505. doi: 10.1371/journal.pgen.1004505. eCollection 2014 Aug.

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Assembly of RNA Polymerase-I Initiation Complex

Description:

References:

TFIIB-related factors in RNA polymerase I transcription.

Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes.

Structure of the initiation-competent RNA polymerase I and its implication for transcription.

Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body.

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Pathways

Assembly of RNA Polymerase-I Initiation Complex

Description:

References:

TFIIB-related factors in RNA polymerase I transcription.

Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes.

Structure of the initiation-competent RNA polymerase I and its implication for transcription.

Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body.

Databases

Tools

Institutional License

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